18^th Immunology of Diabetes Society Congress

19:00 – 19:05

Welcome (5 minutes)

19:05 – 19:35

Plenary Lecture: Current state of T1D Rx and outcomes – closed loop/pumps/sensors - David Maahs (30 minutes)

19:35 – 20:55

Symposium A: Next generation of T1D staging

• Beyond the stages: IBM longitudinal data sets in TEDDY – Peter Achenbach (20 minutes)
• TrialNet omics CMSP data – Eion McKinney and Dirk Homann (20 minutes)
• Risk progression in TrialNet – Emily Sims (20 minutes)
• Discussion (20 minutes)

20:55 – 21:10

Break (15 minutes)

21:10 – 22:30

Symposium B: Islet – Immune Interactions:

• T1D insights from Human Pancreas Analysis Program - Klaus Kaestner (20 minutes)
• Plasticity in human pancreas and islets and immune system in early life - Diane Saunders (20 minutes)
• Lymphocytes from islets and pancreatic lymph nodes - Mike Betts (20 minutes)
• Discussion (20 minutes)

22:30

Adjourn

19:00 – 19:30

Plenary Lecture: Beta cells from stem cells - Doug Melton

(30 minutes)

19:30 – 20:45

Symposium C: Potential pathogenic mechanisms in T1D

• Regulatory T cell signatures – Carolin Daniel (15 minutes)
• “Sterile Inflammation” - Yuval Dor (15 minutes)
• Beta cell stress responses and senescence in T1D – Peter Thompson (15 minutes)
• Lessons from animal models - Helen Thomas (15 minutes)
• Discussion (15 minutes)

20:45 – 20:55

Break (10 minutes)

20:55 – 21:20

• Selected abstracts for oral presentation (20 minutes) 4 abstracts (5 minute presentation)

21:20 – 22:30

• Poster Session (80 minutes)

22:30

Adjourn

19:00 – 19:30

Plenary Lecture (30 minutes)

19:30 – 20:30

Symposium D: Lessons from other diseases

• CD8 T cell programming in cancer and beta cells - Benjamin Youngblood (15 minutes)
• Endotypes in Allergic Diseases/Asthma - Ioana Octavia Agache (15 minutes)
• CAR-Treg therapy in transplantation, lessons for T1D - Megan Levings
• Discussion (15 minutes)

20:30 – 21:30

Special Symposium: T1D interventions – industry perspectives (60 minutes; 8 minutes/speaker)

• Discussion (20 minutes)

21:30 – 21:45

Break (15 minutes)

21:45 – 22:45

Symposium E: Clinical trials consideration

• Responder signatures: Alice Long (15 minutes)
• Combination therapy: Linda Dimeglio (15 minutes)
• TBD (15 minutes)
• Discussion (15 minutes)

22:45

Adjourn

19:00 – 19:30

Plenary Lecture (30 minutes)

19:30 – 20:50

Symposium F: Genetics and other omics - present and future

• New avenues for exploring the genetics of T1D - Kyle Gaulton (15 minutes)
• Genetic influences in T1D - Lorenzo Pasquali (15 minutes)
• Integrating omics into biomarkers of T1D - David Leslie (15 minutes)
• Role of genetics in forming the microbiome in T1D – Eric Triplett (15 minutes)
• Discussion (20 minutes)

20:50 – 21:05

Break (15 minutes)

21:05 – 22:05

Debate – Future Therapies for T1D in 5 years, 10 years, and 20 years?

• Mechanical: Chantal Mathieu (10 minutes)
• Cell transplantation: Tom Kay (10 minutes)
• Immunomodulation: Mark Anderson (10 minutes)
• Discussion (30 minutes)

22:05 – 22:20

Meeting Summary and Looking Forward - Ezio Bonifacio, Marcela Brissova, Chantal Mathieu (Representing views on immunology, beta cells, industry)

22:20 – 22:30

Closing Comments